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KMID : 0043320040270111123
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1123 ~ p.1126
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Protective Constituents Against Sepsis in Mice from the Root Cortex of Paeonia suffruticosa
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Li Gao
Seo Chang-Seob
Lee Kyeung-Seon
Kim Hyo-Jin
Chang Hyun-Wook
Jung Jun-Sub
Song Dong-Keun
Son Jong-Keun
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Abstract
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The bioassay-guided fractionation of protective agents against sepsis-induced lethality from the root cortex of Paeonia suffruticosa ANDREWS (Ranunculaceae) led to the isolation of eight known compounds: paeonol (1), 2,5-dihydroxy-4-methoxyacetophenone (2), acetovanillone (3), paeonoside (4), paeoniflorin (5), oxypaeoniflorin (6), apiopaeonoside (7), and methyl 3-hydroxy-4-methoxybenzoate (8). Among them, 3 showed the highest survival rate (100% with a dose of 30 mg/kg versus 17% for the control experiment) and reduced alanine aminotransferase level to be a half of the control value on the sepsis model induced by lipopolysaccharide/D-galactosamine.
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KEYWORD
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Paeonia suffruticosa, Sepsis, LPS, D-GaIN, ALT
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